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Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

Aurora Kinase A (AURKA) is an oncogenic kinase with major roles in mitosis, but also exerts cell cycle- and kinase-independent functions linked to cancer. Therefore, control of its expression, as well as its activity, is crucial. A short and a long 3′UTR isoform exist for AURKA mRNA, resulting from...

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Detalles Bibliográficos
Autores principales: Cacioppo, Roberta, Akman, Hesna Begum, Tuncer, Taner, Erson-Bensan, Ayse Elif, Lindon, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328522/
https://www.ncbi.nlm.nih.gov/pubmed/37384380
http://dx.doi.org/10.7554/eLife.87253