Cargando…

Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis

APJ has been extensively described in the pathophysiology of angiogenesis and cell proliferation. The prognostic value of APJ overexpression in many diseases is now established. This study aimed to design a PET radiotracer that specifically binds to APJ. Apelin-F13A-NODAGA (AP747) was synthesized an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Louis, Béatrice, Nail, Vincent, Nachar, Oriane, Bouhlel, Ahlem, Moyon, Anaïs, Balasse, Laure, Simoncini, Stéphanie, Chabert, Adrien, Fernandez, Samantha, Brige, Pauline, Hache, Guillaume, Tintaru, Aura, Morgat, Clément, Dignat-George, Françoise, Garrigue, Philippe, Guillet, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2023
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328853/ https://www.ncbi.nlm.nih.gov/pubmed/36973482 http://dx.doi.org/10.1007/s10456-023-09875-8

Ejemplares similares

Succinate Injection Rescues Vasculature and Improves Functional Recovery Following Acute Peripheral Ischemia in Rodents: A Multimodal Imaging Study
por: Moyon, Anaïs, et al.
Publicado: (2021)

Tracking Radiolabeled Endothelial Microvesicles Predicts Their Therapeutic Efficacy: A Proof-of-Concept Study in Peripheral Ischemia Mouse Model Using SPECT/CT Imaging
por: Giraud, Romain, et al.
Publicado: (2022)

Comparison of a New (68)Ga-Radiolabelled PET Imaging Agent sCD146 and RGD Peptide for In Vivo Evaluation of Angiogenesis in Mouse Model of Myocardial Infarction
por: Moyon, Anaïs, et al.
Publicado: (2021)

Early prediction of revascularisation by angiomotin-targeting positron emission tomography
por: Moyon, Anais, et al.
Publicado: (2018)

Sublingual Atropine Administration as a Tool to Decrease Salivary Glands’ PSMA-Ligand Uptake: A Preclinical Proof of Concept Study Using [(68)Ga]Ga-PSMA-11
por: Nail, Vincent, et al.
Publicado: (2022)

The Apelin/APJ System in Psychosis and Neuropathy
por: Lv, Shuang-Yu, et al.
Publicado: (2020)

The Apelin-APJ System in the Evolution of Heart Failure
por: GOIDESCU, CERASELA MIHAELA, et al.
Publicado: (2015)

Expanding role for the apelin/APJ system in physiopathology
por: Carpéné, C., et al.
Publicado: (2007)

The Role of Apelin–APJ System in Diabetes and Obesity
por: Li, Cheng, et al.
Publicado: (2022)

The Role of the Apelin/APJ System in the Regulation of Liver Disease
por: Lv, Xinrui, et al.
Publicado: (2017)

Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
por: Li, Bin, et al.
Publicado: (2021)

Apelin/APJ system: an emerging therapeutic target for neurological diseases
por: Li, Ao, et al.
Publicado: (2022)

Apelin/APJ system: A key therapeutic target for liver disease
por: Lv, Shuang-Yu, et al.
Publicado: (2017)

The Role of Apelin/APJ in a Mouse Model of Oxygen-induced Retinopathy
por: Feng, Jing, et al.
Publicado: (2020)

Apelin/Elabela-APJ: a novel therapeutic target in the cardiovascular system
por: Liu, Wei, et al.
Publicado: (2020)

Study Progression of Apelin/APJ Signaling and Apela in Different Types of Cancer
por: Liu, Longfei, et al.
Publicado: (2021)

Effect of L-Carnitine Supplementation on Apelin and Apelin Receptor (Apj) Expression in Cardiac Muscle of Obese Diabetic Rats
por: Ranjbar Kohan, Neda, et al.
Publicado: (2018)

Apelin-APJ Signaling: a Potential Therapeutic Target for Pulmonary Arterial Hypertension
por: Kim, Jongmin
Publicado: (2014)

Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression
por: Atluri, Pavan, et al.
Publicado: (2006)

Apelin, APJ, and ELABELA: Role in Placental Function, Pregnancy, and Foetal Development—An Overview
por: Dawid, Monika, et al.
Publicado: (2021)

Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors
por: Garrigue, Philippe, et al.
Publicado: (2018)

THE EXPRESSION OF APELIN AND ITS RECEPTOR APJ DURING DIFFERENT PHYSIOLOGICAL STAGES IN THE BOVINE OVARY
por: Schilffarth, Stefanie, et al.
Publicado: (2009)

Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair
por: Walker, Susan, et al.
Publicado: (2014)

Fucoxanthin alters the apelin-13/APJ pathway in certain organs of γ-irradiated mice
por: El Bakary, Nermeen M, et al.
Publicado: (2021)

The beneficial roles of apelin-13/APJ system in cerebral ischemia: Pathogenesis and therapeutic strategies
por: Li, Jiabin, et al.
Publicado: (2022)

Effect of troxerutin on apelin-13, apelin receptors (APJ), and ovarian histological changes in the offspring of high-fat diet fed rats
por: Mehri, Keyvan, et al.
Publicado: (2019)

Stem cell properties of peripheral blood endothelial progenitors are stimulated by soluble CD146 via miR-21: potential use in autologous cell therapy
por: Essaadi, Amel, et al.
Publicado: (2018)

Retraction: Apelin Receptor (APJ) Expression during Cardiopulmonary Bypass in Children Undergoing Surgical Repair
Publicado: (2018)

Xiaoyaosan Improves Depressive-Like Behaviors in Mice through Regulating Apelin-APJ System in Hypothalamus
por: Yan, Zhiyi, et al.
Publicado: (2018)

Apelin13/APJ promotes proliferation of colon carcinoma by activating Notch3 signaling pathway
por: Chen, Tong, et al.
Publicado: (2017)

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target
por: Tian, Yanjun, et al.
Publicado: (2020)

A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [(18)F]fluoride: Will [(18)F]AlF Replace (68)Ga for Metal Chelate Labeling?
por: Fersing, Cyril, et al.
Publicado: (2019)

The Apelin Receptor APJ in Hematopoietic Stem Cells/Progenitor Cells in the Early Stage of Non-Alcoholic Steatohepatitis
por: Ando, Wataru, et al.
Publicado: (2017)

Effect of the spinal apelin-APJ system on the pathogenesis of chronic constriction injury-induced neuropathic pain in rats
por: Xiong, Qingming, et al.
Publicado: (2017)

Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model
por: Yamazaki, Sahori, et al.
Publicado: (2020)

The Apelinergic System: Apelin, ELABELA, and APJ Action on Cell Apoptosis: Anti-Apoptotic or Pro-Apoptotic Effect?
por: Respekta, Natalia, et al.
Publicado: (2022)

Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ
por: Chu, Jiaojiao, et al.
Publicado: (2013)

Interactive Association of Five Candidate Polymorphisms in Apelin/APJ Pathway with Coronary Artery Disease among Chinese Hypertensive Patients
por: Jin, Wei, et al.
Publicado: (2012)

Rapid nanobody-based imaging of mesothelin expressing malignancies compatible with blocking therapeutic antibodies
por: Benloucif, Abdennour, et al.
Publicado: (2023)

Correction: Apelin Ameliorates TNF-α-Induced Reduction of Glycogen Synthesis in the Hepatocytes through G Protein-Coupled Receptor APJ
por: Chu, Jiaojiao, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_nvpbe7lqabcfsitbfljj0airu6