Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented as an immunotherapeutic candidate, partly due to a lack of structural info...

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Detalles Bibliográficos
Autores principales: Abendstein, Leoni, Dijkstra, Douwe J., Tjokrodirijo, Rayman T. N., van Veelen, Peter A., Trouw, Leendert A., Hensbergen, Paul J., Sharp, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328927/
https://www.ncbi.nlm.nih.gov/pubmed/37419978
http://dx.doi.org/10.1038/s41467-023-39788-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328927/
https://www.ncbi.nlm.nih.gov/pubmed/37419978
http://dx.doi.org/10.1038/s41467-023-39788-5

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