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Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and enhanced effector functions, including highly efficient pathogen neutralisation and complement activation. It is also underrepresented as an immunotherapeutic candidate, partly due to a lack of structural info...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328927/ https://www.ncbi.nlm.nih.gov/pubmed/37419978 http://dx.doi.org/10.1038/s41467-023-39788-5 |