Optimal strategies for learning multi-ancestry polygenic scores vary across traits

Polygenic scores (PGSs) are individual-level measures that aggregate the genome-wide genetic predisposition to a given trait. As PGS have predominantly been developed using European-ancestry samples, trait prediction using such European ancestry-derived PGS is less accurate in non-European ancestry...

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Detalles Bibliográficos
Autores principales: Lehmann, Brieuc, Mackintosh, Maxine, McVean, Gil, Holmes, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328935/
https://www.ncbi.nlm.nih.gov/pubmed/37419925
http://dx.doi.org/10.1038/s41467-023-38930-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10328935/
https://www.ncbi.nlm.nih.gov/pubmed/37419925
http://dx.doi.org/10.1038/s41467-023-38930-7

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