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Tuning DO:DM Ratios Modulates MHC Class II Immunopeptidomes

Major histocompatibility complex class II (MHC-II) antigen presentation underlies a wide range of immune responses in health and disease. However, how MHC-II antigen presentation is regulated by the peptide-loading catalyst HLA-DM (DM), its associated modulator, HLA-DO (DO), is incompletely understo...

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Detalles Bibliográficos
Autores principales: Olsson, Niclas, Jiang, Wei, Adler, Lital N., Mellins, Elizabeth D., Elias, Joshua E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329146/
https://www.ncbi.nlm.nih.gov/pubmed/35085787
http://dx.doi.org/10.1016/j.mcpro.2022.100204