Cargando…

Cutoff value of IC(50) for drug sensitivity in patient-derived tumor organoids in colorectal cancer

Patient-derived tumor organoids (PDTOs) have the potential to be used to predict the patient response to chemotherapy. However, the cutoff value of the half-maximal inhibition concentration (IC(50)) for PDTO drug sensitivity has not been validated with clinical cohort data. We established PDTOs and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Yuting, Wang, Ting, Hu, Yaowen, Ji, Hongli, Yan, Botao, Hu, Xiarong, Zeng, Yunli, Hao, Yifan, Xue, Weisong, Chen, Zexin, Lan, Jianqiang, Wang, Yanan, Deng, Haijun, Deng, Chuxia, Wu, Xiufeng, Yan, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329174/ https://www.ncbi.nlm.nih.gov/pubmed/37426352 http://dx.doi.org/10.1016/j.isci.2023.107116

Ejemplares similares

Patient-Derived Tumor Organoids Can Predict the Progression-Free Survival of Patients With Stage IV Colorectal Cancer After Surgery
por: Wang, Ting, et al.
Publicado: (2023)

Use of patient‐derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer
por: Xue, Weisong, et al.
Publicado: (2023)

Indocyanine green for radical lymph node dissection in patients with sigmoid and rectal cancer: randomized clinical trial
por: Wan, Jinliang, et al.
Publicado: (2022)

Variations in IC(50) Values with Purity of Mushroom Tyrosinase
por: Neeley, Elizabeth, et al.
Publicado: (2009)

Proteochemometric Method for pIC50 Prediction of Flaviviridae
por: Singh, Divye, et al.
Publicado: (2022)

IC(50)-to-K(i): a web-based tool for converting IC(50) to K(i) values for inhibitors of enzyme activity and ligand binding
por: Cer, R. Z., et al.
Publicado: (2009)

Comparability of Mixed IC(50) Data – A Statistical Analysis
por: Kalliokoski, Tuomo, et al.
Publicado: (2013)

The changing 50% inhibitory concentration (IC(50)) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer
por: He, Yifeng, et al.
Publicado: (2016)

Gene-signature-derived IC(50)s/EC(50)s reflect the potency of causative upstream targets and downstream phenotypes
por: Renner, Steffen, et al.
Publicado: (2020)

Beyond IC(50)s: Towards Robust Statistical Methods for in vitro Association Studies
por: Beam, Andrew, et al.
Publicado: (2014)

A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC(50)
por: Zhang, Hui, et al.
Publicado: (2013)

When Does the IC(50) Accurately Assess the Blocking Potency of a Drug?
por: Gomis-Tena, Julio, et al.
Publicado: (2020)

How high is too high in cutoff levels from 50-g glucose challenge test
por: Cha, Hyun-Hwa, et al.
Publicado: (2016)

Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts
por: Xiao, Dongchang, et al.
Publicado: (2020)

Predicting the DPP-IV Inhibitory Activity pIC(50) Based on Their Physicochemical Properties
por: Gu, Tianhong, et al.
Publicado: (2013)

Application of non-invasive prenatal testing in screening chromosomal aberrations in pregnancies with different nuchal translucency cutoffs
por: Xu, Yong, et al.
Publicado: (2023)

Identification of Shigella flexneri IcsA Residues Affecting Interaction with N-WASP, and Evidence for IcsA-IcsA Co-Operative Interaction
por: Teh, Min Yan, et al.
Publicado: (2013)

In Celebration of Dr. Mario R. Capecchi's Nobel Prize
por: Deng, Chuxia
Publicado: (2007)

Terpenes Increase the Lipid Dynamics in the Leishmania Plasma Membrane at Concentrations Similar to Their IC(50) Values
por: Camargos, Heverton Silva, et al.
Publicado: (2014)

IC(50): an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
por: Xu, Yipeng, et al.
Publicado: (2022)

On Approximating the pIC(50) Value of COVID-19 Medicines In Silico with Artificial Neural Networks
por: Baressi Šegota, Sandi, et al.
Publicado: (2023)

Developing Biliary Atresia-like Model by Treating Human Liver Organoids with Polyinosinic:Polycytidylic Acid (Poly (I:C))
por: Chung, Patrick Ho-Yu, et al.
Publicado: (2022)

Performance Comparisons of AlexNet and GoogLeNet in Cell Growth Inhibition IC50 Prediction
por: Lee, Yeeun, et al.
Publicado: (2021)

Corrigendum: IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
Publicado: (2023)

Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression
por: Chen, Siyuan, et al.
Publicado: (2021)

Organoid Transplantation Can Improve Reproductive Prognosis by Promoting Endometrial Repair in Mice
por: Zhang, Huixing, et al.
Publicado: (2022)

Sample‐to‐cutoff ratios using Architect HIV Ag/Ab Combo: The influence with the results of supplemental tests and optimal cutoff value to predict HIV infection
por: Wang, Linchuan, et al.
Publicado: (2019)

An Unknown Piece of Early Work of Nuclear Reprogramming in Fish Eggs
por: Deng, Chuxia, et al.
Publicado: (2010)

Recent advances in organotypic tissue slice cultures for anticancer drug development
por: He, Lin, et al.
Publicado: (2022)

Organoids containing neural-like cells derived from chicken iPSCs respond to poly:IC through the RLR family
por: Katayama, Masafumi, et al.
Publicado: (2023)

Modeling retinitis pigmentosa through patient-derived retinal organoids
por: Li, Yan-Ping, et al.
Publicado: (2021)

IC Reference
por: Dolmazon, Emeline
Publicado: (2019)

Effect of Inducers, Incubation Time and Heme Concentration on IC(50) Value Variation in Anti-heme Crystallization Assay
por: Nhien, Nguyen Thanh Thuy, et al.
Publicado: (2011)

A novel application of t-statistics to objectively assess the quality of IC(50) fits for P-glycoprotein and other transporters
por: O'Connor, Michael, et al.
Publicado: (2015)

IC(50) Evaluation of Platinum Nanocatalysts for Cancer Treatment in Fibroblast, HeLa, and DU-145 Cell Lines
por: González-Larraza, Pamela G., et al.
Publicado: (2020)

Numerical learning of deep features from drug-exposed cell images to calculate IC50 without staining
por: Cho, Kookrae, et al.
Publicado: (2022)

Workshop on Impedance beyond Cutoff
por: Chattopadhyay, S
Publicado: (1990)

Age cutoff in lymphoma diagnosis
por: Ok, Chi Y., et al.
Publicado: (2015)

Cutoff Finder: A Comprehensive and Straightforward Web Application Enabling Rapid Biomarker Cutoff Optimization
por: Budczies, Jan, et al.
Publicado: (2012)

High-cutoff hemodialysis in multiple myeloma patients with acute kidney injury
por: Xing, Yan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pq8r5qcer3a95djisef6e6o98b