Gut microbiota-derived tryptophan metabolites alleviate liver injury via AhR/Nrf2 activation in pyrrolizidine alkaloids-induced sinusoidal obstruction syndrome

BACKGROUND AND AIMS: Hepatic sinusoidal obstruction syndrome (HSOS) is caused by toxic injury, such as pyrrolizidine alkaloids, to the liver sinusoidal endothelial cells, and the gut microbiota may be involved. However, the specific role and underlying mechanism of gut microbiota in HSOS is unknown....

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Detalles Bibliográficos
Autores principales: Shang, Haitao, Huang, Chao, Xiao, Zhuanglong, Yang, Pengcheng, Zhang, Shengyan, Hou, Xiaohua, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329330/
https://www.ncbi.nlm.nih.gov/pubmed/37422682
http://dx.doi.org/10.1186/s13578-023-01078-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329330/
https://www.ncbi.nlm.nih.gov/pubmed/37422682
http://dx.doi.org/10.1186/s13578-023-01078-4

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