Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

BACKGROUND: Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. METHODS: To identify responsible surface proteins, we performed deep proteome profiling on minute numbers o...

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Detalles Bibliográficos
Autores principales: Bahrami, Ehsan, Schmid, Jan Philipp, Jurinovic, Vindi, Becker, Martin, Wirth, Anna-Katharina, Ludwig, Romina, Kreissig, Sophie, Duque Angel, Tania Vanessa, Amend, Diana, Hunt, Katharina, Öllinger, Rupert, Rad, Roland, Frenz, Joris Maximilian, Solovey, Maria, Ziemann, Frank, Mann, Matthias, Vick, Binje, Wichmann, Christian, Herold, Tobias, Jayavelu, Ashok Kumar, Jeremias, Irmela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329331/
https://www.ncbi.nlm.nih.gov/pubmed/37422628
http://dx.doi.org/10.1186/s12943-023-01803-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329331/
https://www.ncbi.nlm.nih.gov/pubmed/37422628
http://dx.doi.org/10.1186/s12943-023-01803-0

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