Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2

BACKGROUND: SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–76 amino acid viroporin that is crucial for...

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Detalles Bibliográficos
Autores principales: Breitinger, Ulrike, Sedky, Christine Adel, Sticht, Heinrich, Breitinger, Hans-Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329798/
https://www.ncbi.nlm.nih.gov/pubmed/37422646
http://dx.doi.org/10.1186/s12985-023-02095-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329798/
https://www.ncbi.nlm.nih.gov/pubmed/37422646
http://dx.doi.org/10.1186/s12985-023-02095-y

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