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Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2
BACKGROUND: SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the search for pharmaceutical targets against COVID-19 remains an important challenge. Here, we studied the envelope protein E of SARS-CoV and SARS-CoV-2, a highly conserved 75–76 amino acid viroporin that is crucial for...
Autores principales: | Breitinger, Ulrike, Sedky, Christine Adel, Sticht, Heinrich, Breitinger, Hans-Georg |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329798/ https://www.ncbi.nlm.nih.gov/pubmed/37422646 http://dx.doi.org/10.1186/s12985-023-02095-y |
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