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In silico-in vitro modeling to uncover cues involved in establishing microglia identity: TGF-β3 and laminin can drive microglia signature gene expression

Microglia are the resident macrophages of the central nervous system (CNS) and play a key role in CNS development, homeostasis, and disease. Good in vitro models are indispensable to study their cellular biology, and although much progress has been made, in vitro cultures of primary microglia still...

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Detalles Bibliográficos
Autores principales: Timmerman, Raissa, Zuiderwijk-Sick, Ella Alwine, Baron, Wia, Bajramovic, Jeffrey John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10330817/
https://www.ncbi.nlm.nih.gov/pubmed/37435046
http://dx.doi.org/10.3389/fncel.2023.1178504