The p53 challenge of hematopoietic stem cell gene editing

Ex vivo gene editing in hematopoietic stem and progenitor cells (HSPCs) represents a promising curative treatment strategy for monogenic blood disorders. Gene editing using the homology-directed repair (HDR) pathway enables precise genetic modifications ranging from single base pair correction to re...

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Detalles Bibliográficos
Autores principales: Dorset, Sofie R., Bak, Rasmus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331021/
https://www.ncbi.nlm.nih.gov/pubmed/37435043
http://dx.doi.org/10.1016/j.omtm.2023.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331021/
https://www.ncbi.nlm.nih.gov/pubmed/37435043
http://dx.doi.org/10.1016/j.omtm.2023.06.003

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