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The p53 challenge of hematopoietic stem cell gene editing
Ex vivo gene editing in hematopoietic stem and progenitor cells (HSPCs) represents a promising curative treatment strategy for monogenic blood disorders. Gene editing using the homology-directed repair (HDR) pathway enables precise genetic modifications ranging from single base pair correction to re...
Autores principales: | Dorset, Sofie R., Bak, Rasmus O. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331021/ https://www.ncbi.nlm.nih.gov/pubmed/37435043 http://dx.doi.org/10.1016/j.omtm.2023.06.003 |
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