Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β

INTRODUCTION: Lomerizine is a calcium channel blocker that crosses the blood–brain barrier and is used clinically in the treatment of migraines. However, whether lomerizine is beneficial in modulating neuroinflammatory responses has not been tested yet. METHODS: To assess the potential of lomerizine...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Jin-Hee, Hwang, Jeong-Woo, Lee, Hyun-ju, Jang, Geum Mi, Jeong, Yoo Joo, Cho, Joonho, Seo, Jinsoo, Hoe, Hyang-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331167/
https://www.ncbi.nlm.nih.gov/pubmed/37435081
http://dx.doi.org/10.3389/fimmu.2023.1150940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331167/
https://www.ncbi.nlm.nih.gov/pubmed/37435081
http://dx.doi.org/10.3389/fimmu.2023.1150940

Ejemplares similares