Cargando…

Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback

The aryl hydrocarbon receptor (AHR) exerts major roles in xenobiotic metabolism, and in immune and barrier tissue homeostasis. How AHR activity is regulated by the availability of endogenous ligands is poorly understood. Potent AHR ligands have been shown to exhibit a negative feedback loop through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Fangcong, Annalora, Andrew J, Murray, Iain A, Tian, Yuan, Marcus, Craig B, Patterson, Andrew D, Perdew, Gary H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331327/ https://www.ncbi.nlm.nih.gov/pubmed/37434789 http://dx.doi.org/10.1177/11786469231182508

Ejemplares similares

Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation
por: Morgan, Ethan W, et al.
Publicado: (2023)

Intestinal microbiota-derived tryptophan metabolites are predictive of Ah receptor activity
por: Dong, Fangcong, et al.
Publicado: (2020)

How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function
por: Murray, Iain A., et al.
Publicado: (2020)

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR
por: Manzella, Christopher, et al.
Publicado: (2018)

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands
por: Manzella, Christopher R., et al.
Publicado: (2020)

Induction of AHR Signaling in Response to the Indolimine Class of Microbial Stress Metabolites
por: Patel, Dhwani, et al.
Publicado: (2023)

Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity
por: Muku, Gulsum E., et al.
Publicado: (2019)

Multiscale Simulations on the Catalytic Plasticity of CYP76AH1
por: Qiu, Yufan, et al.
Publicado: (2021)

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis
por: Zelante, Teresa, et al.
Publicado: (2014)

Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses
por: Muku, Gulsum E., et al.
Publicado: (2017)

Dissociable Effects of Tryptophan Supplementation on Negative Feedback Sensitivity and Reversal Learning
por: Thirkettle, Martin, et al.
Publicado: (2019)

Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity
por: Vogel, Christoph F.A., et al.
Publicado: (2016)

Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter
por: Xie, Xuan, et al.
Publicado: (2018)

AhR activation underlies the CYP1A autoinduction by A-998679 in rats
por: Liguori, Michael J., et al.
Publicado: (2012)

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay
por: Dong, Fangcong, et al.
Publicado: (2020)

Ah receptor represses acute phase response gene expression without binding to its cognate response element
por: Patel, Rushang D., et al.
Publicado: (2009)

UVB Radiation and Selected Tryptophan-Derived AhR Ligands—Potential Biological Interactions in Melanoma Cells
por: Walczak, Katarzyna, et al.
Publicado: (2021)

Cytochrome P450 1B1: A Key Regulator of Ocular Iron Homeostasis and Oxidative Stress
por: Song, Yong-Seok, et al.
Publicado: (2022)

Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway
por: Xie, Jiebin, et al.
Publicado: (2021)

A novel AhR ligand, 2AI, protects the retina from environmental stress
por: Gutierrez, Mark A., et al.
Publicado: (2016)

A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes
por: Szelest, Monika, et al.
Publicado: (2021)

Ah Receptor Binding to its Cognate Response Element is Required for Dioxin-Mediated Toxicity
por: Perdew, Gary H.
Publicado: (2008)

Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes
por: Zhou, Bing, et al.
Publicado: (2017)

ECMO, ARDS and AH1N1
por: Zangrillo, A
Publicado: (2009)

StemRegenin-1 Attenuates Endothelial Progenitor Cell Senescence by Regulating the AhR Pathway-Mediated CYP1A1 and ROS Generation
por: Lim, Hye Ji, et al.
Publicado: (2023)

ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1
por: Liu, Peng, et al.
Publicado: (2022)

SVEP1 is an endogenous ligand for the orphan receptor PEAR1
por: Elenbaas, Jared S., et al.
Publicado: (2023)

The neuroprotective action of 3,3′-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling
por: Rzemieniec, J., et al.
Publicado: (2019)

L-DOPA Is an Endogenous Ligand for OA1
por: Lopez, Vanessa M, et al.
Publicado: (2008)

Effect of TBT and PAHs on CYP1A, AhR and Vitellogenin Gene Expression in the Japanese Eel, Anguilla japonica
por: Choi, Min Seop, et al.
Publicado: (2012)

Taxifolin Inhibits 7,12-Dimethylbenz(a)anthracene-induced Breast Carcinogenesis by Regulating AhR/CYP1A1 Signaling Pathway
por: Haque, Md. Wasimul, et al.
Publicado: (2017)

Coactivator Recruitment of AhR/ARNT1
por: Endler, Alexander, et al.
Publicado: (2014)

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma
por: Zhan, Yizhi, et al.
Publicado: (2022)

AhIRT1 and AhNRAMP1 metal transporter expression correlates with Cd uptake in peanuts under iron deficiency
por: Chen, Chu, et al.
Publicado: (2017)

Author Correction: SVEP1 is an endogenous ligand for the orphan receptor PEAR1
por: Elenbaas, Jared S., et al.
Publicado: (2023)

Evaluation of the Ecological Environment Affected by Cry1Ah1 in Poplar
por: Movahedi, Ali, et al.
Publicado: (2022)

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
por: Kapelyukh, Y., et al.
Publicado: (2019)

Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques
por: UNO, Yasuhiro, et al.
Publicado: (2014)

PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model
por: Rondelli, Catherine M., et al.
Publicado: (2016)

Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis
por: Yoshikawa, Yuri, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9a1g41dsj93o2271maotjn044d