Cargando…

Selective modulation of activated protein C activities by a nonactive site–targeting nanobody library

Activated protein C (APC) is a pleiotropic coagulation protease with anticoagulant, anti-inflammatory, and cytoprotective activities. Selective modulation of these APC activities contributes to our understanding of the regulation of these physiological mechanisms and permits the development of thera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sim, Derek S., Shukla, Meenal, Mallari, Cornell R., Fernández, José A., Xu, Xiao, Schneider, Doug, Bauzon, Maxine, Hermiston, Terry W., Mosnier, Laurent O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Thrombosis and Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331410/ https://www.ncbi.nlm.nih.gov/pubmed/36735416 http://dx.doi.org/10.1182/bloodadvances.2022008740

Ejemplares similares

An engineered activated factor V for the prevention and treatment of acute traumatic coagulopathy and bleeding in mice
por: Joseph, Bilgimol Chumappumkal, et al.
Publicado: (2022)

Targeting complement activation in COVID-19
por: Kulkarni, Hrishikesh S., et al.
Publicado: (2020)

Novel mechanism regulating tissue factor activity
por: Nieuwland, Rienk
Publicado: (2021)

Tumor-expressed factor VII is associated with survival and regulates tumor progression in breast cancer
por: Kroone, Chantal, et al.
Publicado: (2023)

Tissue factor activates the coagulation cascade in mouse models of acute promyelocytic leukemia
por: Hisada, Yohei, et al.
Publicado: (2023)

The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans
por: Han, Lulu, et al.
Publicado: (2021)

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke
por: Dhanesha, Nirav, et al.
Publicado: (2022)

Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19
por: Henderson, Michael W., et al.
Publicado: (2022)

Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice
por: Grover, Steven P., et al.
Publicado: (2022)

Polyphosphate expression by cancer cell extracellular vesicles mediates binding of factor XII and contact activation
por: Shim, Young Jun, et al.
Publicado: (2021)

Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
por: Shamanaev, Aleksandr, et al.
Publicado: (2022)

Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance
por: Jankowska, Katarzyna I., et al.
Publicado: (2022)

Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity
por: Zheng, Tony J., et al.
Publicado: (2022)

Mapping the prothrombin-binding site of pseutarin C by site-directed PEGylation
por: Üstok, Fatma Işık, et al.
Publicado: (2022)

The interplay between tissue plasminogen activator domains and fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies
por: Longstaff, Colin, et al.
Publicado: (2011)

Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo
por: Chen, Zu-Lin, et al.
Publicado: (2022)

A novel von Willebrand factor multimer ratio as marker of disease activity in thrombotic thrombocytopenic purpura
por: Falter, Tanja, et al.
Publicado: (2023)

In vitro characterization of CT‐001—a short‐acting factor VIIa with enhanced prohemostatic activity
por: Sim, Derek S., et al.
Publicado: (2021)

Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as a therapeutic target in COVID-19
por: Weiss, Lukas J., et al.
Publicado: (2022)

Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
por: Andersson, Helena M., et al.
Publicado: (2010)

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
por: Yu, Jia, et al.
Publicado: (2020)

Platelet binding to polymerizing fibrin is avidity driven and requires activated αIIbβ3 but not fibrin cross-linking
por: Buitrago, Lorena, et al.
Publicado: (2021)

Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C
por: Jiang, Miao, et al.
Publicado: (2022)

A flow cytometric assay to detect platelet-activating antibodies in VITT after ChAdOx1 nCov-19 vaccination
por: Handtke, Stefan, et al.
Publicado: (2021)

Anti-HK antibody reveals critical roles of a 20-residue HK region for Aβ-induced plasma contact system activation
por: Chen, Zu-Lin, et al.
Publicado: (2022)

A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia
por: Koukouritaki, Sevasti B., et al.
Publicado: (2023)

Absence of hyperfibrinolysis may explain lack of efficacy of tranexamic acid in hypoproliferative thrombocytopenia
por: Ilich, Anton, et al.
Publicado: (2022)

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry
por: Gomez-Builes, J. Carolina, et al.
Publicado: (2018)

Platelets inhibit apoptotic lung epithelial cell death and protect mice against infection-induced lung injury
por: Bain, William, et al.
Publicado: (2019)

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection
por: Al-Samkari, Hanny, et al.
Publicado: (2020)

COVID-19 coagulopathy, thrombosis, and bleeding
por: Chan, Noel C., et al.
Publicado: (2020)

Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective study
por: Hill, Jason B., et al.
Publicado: (2020)

A toolkit for the collection of thrombosis-related data elements in COVID-19 clinical studies
por: Siegal, Deborah M., et al.
Publicado: (2020)

Incidence of symptomatic, image-confirmed venous thromboembolism following hospitalization for COVID-19 with 90-day follow-up
por: Salisbury, Richard, et al.
Publicado: (2020)

Postdischarge thromboembolic outcomes and mortality of hospitalized patients with COVID-19: the CORE-19 registry
por: Giannis, Dimitrios, et al.
Publicado: (2021)

A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice
por: Østergaard, Henrik, et al.
Publicado: (2021)

COVID-19 and VITT: same or different?
por: Arepally, Gowthami M.
Publicado: (2021)

von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene
por: Sadler, Brooke, et al.
Publicado: (2021)

An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function
por: Pijning, Aster E., et al.
Publicado: (2021)

The incidence of cancer-associated thrombosis is increasing over time
por: Mahajan, Anjlee, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_j27j4ajqqo1hmq01b5p8drjtm6