Targeting apolipoprotein E and N-terminal amyloid β-protein precursor interaction improves cognition and reduces amyloid pathology in Alzheimer’s mice

Apolipoprotein E (apoE) interaction with amyloid β-protein precursor (APP) has garnered attention as the therapeutic target for Alzheimer’s disease (AD). Having discovered the apoE antagonist (6KApoEp) that blocks apoE binding to N-terminal APP, we tested the therapeutic potential of 6KApoEp on AD-r...

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Detalles Bibliográficos
Autores principales: Sawmiller, Darrell, Koyama, Naoki, Fujiwara, Masakazu, Segawa, Tatsuya, Maeda, Masahiro, Mori, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article Collection: Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331488/
https://www.ncbi.nlm.nih.gov/pubmed/37211092
http://dx.doi.org/10.1016/j.jbc.2023.104846

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331488/
https://www.ncbi.nlm.nih.gov/pubmed/37211092
http://dx.doi.org/10.1016/j.jbc.2023.104846

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