Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl‐tRNA synthetase 1

Prolyl‐tRNA synthetase 1 (PARS1) has attracted much interest in controlling pathologic accumulation of collagen containing high amounts of proline in fibrotic diseases. However, there are concerns about its catalytic inhibition for potential adverse effects on global protein synthesis. We developed...

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Detalles Bibliográficos
Autores principales: Yoon, Ina, Kim, Sulhee, Cho, Minjae, You, Kyung Ah, Son, Jonghyeon, Lee, Caroline, Suh, Ji Hun, Bae, Da‐Jeong, Kim, Jong Min, Oh, Sinae, Park, Songhwa, Kim, Sanga, Cho, Seong Hyeok, Park, Seonha, Bang, Kyuhyeon, Seo, Minjeong, Kim, Jong Hyun, Lee, Bongyong, Park, Joon Seok, Hwang, Kwang Yeon, Kim, Sunghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331583/
https://www.ncbi.nlm.nih.gov/pubmed/37212275
http://dx.doi.org/10.15252/emmm.202216940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331583/
https://www.ncbi.nlm.nih.gov/pubmed/37212275
http://dx.doi.org/10.15252/emmm.202216940

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