A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder affecting 1 in 500 people in the general population. Characterized by asymmetric left ventricular hypertrophy, cardiomyocyte disarray and cardiac fibrosis, HCM is a highly complex disease with heterogenous clinica...

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Detalles Bibliográficos
Autores principales: Chou, Chun, Martin, Gregory L., Perera, Gayani, Awata, Junya, Larson, Amy, Blanton, Robert, Chin, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331725/
https://www.ncbi.nlm.nih.gov/pubmed/37435054
http://dx.doi.org/10.3389/fcvm.2023.1223244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331725/
https://www.ncbi.nlm.nih.gov/pubmed/37435054
http://dx.doi.org/10.3389/fcvm.2023.1223244

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