The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord

Background: Opioids are efficacious and safe analgesic drugs in short-term use for acute pain but chronic use can lead to tolerance and dependence. Opioid-induced microglial activation may contribute to the development of tolerance and this process may differ between males and females. A link is sug...

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Detalles Bibliográficos
Autores principales: Ahlström, Fredrik HG, Viisanen, Hanna, Karhinen, Leena, Mätlik, Kert, Blomqvist, Kim J, Lilius, Tuomas O, Sidorova, Yulia A, Palada, Vinko, Rauhala, Pekka V, Kalso, Eija A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331785/
https://www.ncbi.nlm.nih.gov/pubmed/37285551
http://dx.doi.org/10.1177/17448069231183902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331785/
https://www.ncbi.nlm.nih.gov/pubmed/37285551
http://dx.doi.org/10.1177/17448069231183902

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