Cargando…

The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord

Background: Opioids are efficacious and safe analgesic drugs in short-term use for acute pain but chronic use can lead to tolerance and dependence. Opioid-induced microglial activation may contribute to the development of tolerance and this process may differ between males and females. A link is sug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahlström, Fredrik HG, Viisanen, Hanna, Karhinen, Leena, Mätlik, Kert, Blomqvist, Kim J, Lilius, Tuomas O, Sidorova, Yulia A, Palada, Vinko, Rauhala, Pekka V, Kalso, Eija A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331785/ https://www.ncbi.nlm.nih.gov/pubmed/37285551 http://dx.doi.org/10.1177/17448069231183902

Ejemplares similares

Spared Nerve Injury Causes Sexually Dimorphic Mechanical Allodynia and Differential Gene Expression in Spinal Cords and Dorsal Root Ganglia in Rats
por: Ahlström, F.H.G., et al.
Publicado: (2021)

Novel RET agonist for the treatment of experimental neuropathies
por: Viisanen, Hanna, et al.
Publicado: (2020)

Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat
por: Lilius, T O, et al.
Publicado: (2015)

Electrochemical Detection of Morphine in Untreated Human Capillary Whole Blood
por: Verrinder, Elsi, et al.
Publicado: (2021)

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat
por: Sidorova, Yulia A., et al.
Publicado: (2017)

Simultaneous Detection of Morphine and Codeine in the Presence of Ascorbic Acid and Uric Acid and in Human Plasma at Nafion Single-Walled Carbon Nanotube Thin-Film Electrode
por: Wester, Niklas, et al.
Publicado: (2019)

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging
por: Geng, Li, et al.
Publicado: (2020)

Disposable Nafion-Coated Single-Walled Carbon Nanotube Test Strip for Electrochemical Quantitative Determination of Acetaminophen in a Finger-Prick Whole Blood Sample
por: Wester, Niklas, et al.
Publicado: (2020)

Chloride Intracellular Channel Protein 2 Promotes Microglial Invasion: A Link to Microgliosis in the Parkinson’s Disease Brain
por: Choudhury, Mohammed E., et al.
Publicado: (2022)

Author Correction: Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging
por: Geng, Li, et al.
Publicado: (2023)

L1 Antisense Promoter Drives Tissue-Specific Transcription of Human Genes
por: Mätlik, Kert, et al.
Publicado: (2006)

From microRNA target validation to therapy: lessons learned from studies on BDNF
por: Varendi, Kärt, et al.
Publicado: (2015)

Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury
por: Anttila, Jenni E., et al.
Publicado: (2018)

Combination of native and denaturing PAGE for the detection of protein binding regions in long fragments of genomic DNA
por: Kaer, Kristel, et al.
Publicado: (2008)

Electrochemical Detection of Oxycodone and Its Main Metabolites with Nafion-Coated Single-Walled Carbon Nanotube Electrodes
por: Mynttinen, Elsi, et al.
Publicado: (2020)

Distinct Pattern of Microgliosis in the Olfactory Bulb of Neurodegenerative Proteinopathies
por: Kohl, Zacharias, et al.
Publicado: (2017)

Predicting long-term response to strong opioids in patients with low back pain: findings from a randomized, controlled trial of transdermal fentanyl and morphine
por: Kalso, Eija, et al.
Publicado: (2007)

Reduction of astrogliosis and microgliosis by cerebrospinal fluid shunting in experimental hydrocephalus
por: Miller, Janet M, et al.
Publicado: (2007)

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis
por: Manocha, Gunjan D., et al.
Publicado: (2015)

Cspg4(high) microglia contribute to microgliosis during neurodegeneration
por: Liu, Ya-jing, et al.
Publicado: (2023)

Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
por: Pan, Yinbing, et al.
Publicado: (2016)

Cerebral Dopamine Neurotrophic Factor Diffuses Around the Brainstem and Does Not Undergo Anterograde Transport After Injection to the Substantia Nigra
por: Albert, Katrina, et al.
Publicado: (2019)

Astrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson’s disease
por: Flores-Cuadrado, Alicia, et al.
Publicado: (2021)

Reactive Microgliosis in Sepsis-Associated and Acute Hepatic Encephalopathies: An Ultrastructural Study
por: Shulyatnikova, Tatyana, et al.
Publicado: (2022)

Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway
por: Yang, Yaqiong, et al.
Publicado: (2021)

Anti-CD20 inhibits T cell-mediated pathology and microgliosis in the rat brain
por: Anthony, Daniel C, et al.
Publicado: (2014)

Heat-Shock Induces Granule Cell Dispersion and Microgliosis in Hippocampal Slice Cultures
por: Weninger, Jasmin, et al.
Publicado: (2021)

Oral Pathogenic Bacteria-Inducing Neurodegenerative Microgliosis in Human Neural Cell Platform
por: Tran, Van Thi Ai, et al.
Publicado: (2021)

Nicotinamide enhances myelin production after demyelination through reduction of astrogliosis and microgliosis
por: Kaplanis, Stefanos Ioannis, et al.
Publicado: (2023)

Quantitative evidence of suppressed TMEM119 microglial immunohistochemistry in fatal morphine intoxications
por: Bohnert, Simone, et al.
Publicado: (2021)

A Molecular Signature of Myalgia in Myotonic Dystrophy 2
por: Moshourab, Rabih, et al.
Publicado: (2016)

Worse health‐related quality of life, impaired functioning and psychiatric comorbidities are associated with excess mortality in patients with severe chronic pain
por: Vartiainen, Pekka, et al.
Publicado: (2022)

Infiltrative microgliosis: activation and long-distance migration of subependymal microglia following periventricular insults
por: Carbonell, W Shawn, et al.
Publicado: (2005)

Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury
por: Wlaschin, Josette J, et al.
Publicado: (2018)

Dietary Curcumin Prevented Astrocytosis, Microgliosis, and Apoptosis Caused by Acute and Chronic Exposure to Ozone
por: Nery-Flores, Sendar Daniel, et al.
Publicado: (2019)

Tumor necrosis factor (TNF) induces astrogliosis, microgliosis and promotes survival of cortical neurons
por: Abd-El-Basset, Ebtesam M, et al.
Publicado: (2021)

Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis
por: Maheshwari, Upasana, et al.
Publicado: (2023)

Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1
por: Peng, Jialing, et al.
Publicado: (2022)

Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra
por: Mätlik, Kert, et al.
Publicado: (2017)

Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis
por: Palada, Vinko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hsl2mnegmn95phouvi87atte09