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Convergent micro-wave assisted synthesis of quinazolinone and its precursor using the bio-sourced solvent pinane

A general microwave synthesis of 4-oxo-3,4-dihydroquinazolin-2-yl propanoic acids and their diamide precursors from the corresponding substituted benzamide and succinic anhydride is described, using pinane as a sustainable solvent that favors the cyclization step. The conditions are some of the most...

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Detalles Bibliográficos
Autores principales: Richieu, Antoine, Bertrand, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331922/
https://www.ncbi.nlm.nih.gov/pubmed/37435375
http://dx.doi.org/10.1039/d3ra03702a