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The role of TET2-mediated ROBO4 hypomethylation in the development of diabetic retinopathy

BACKGROUND: In diabetic retinopathy, increasing evidence points to a link between the pathogenesis of retinal microangiopathy and the endothelial cell-specific factor roundabout4 (ROBO4). According to earlier research, specificity protein 1 (SP1) enhances the binding to the ROBO4 promoter, increasin...

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Detalles Bibliográficos
Autores principales: Zhao, Liangliang, Xu, Haitao, Liu, Xin, Cheng, Yan, Xie, Jia’nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332081/
https://www.ncbi.nlm.nih.gov/pubmed/37430272
http://dx.doi.org/10.1186/s12967-023-04310-4