Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia

Achondroplasia (ACH) is a common skeletal dysplasia characterized by a disproportionately short stature. We found that meclizine, which is an over-the-counter drug for motion sickness, inhibited the fibroblast growth factor receptor 3 (FGFR3) gene using a drug repositioning strategy, and meclizine 1...

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Detalles Bibliográficos
Autores principales: Matsushita, Masaki, Kitoh, Hiroshi, Mishima, Kenichi, Kamiya, Yasunari, Kato, Daisaku, Takemoto, Genta, Sawamura, Kenta, Ueno, Shinji, Yasuhiro, Nakai, Nishida, Kazuki, Imagama, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332602/
https://www.ncbi.nlm.nih.gov/pubmed/37428729
http://dx.doi.org/10.1371/journal.pone.0283425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10332602/
https://www.ncbi.nlm.nih.gov/pubmed/37428729
http://dx.doi.org/10.1371/journal.pone.0283425

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