Impaired biosynthesis of ergosterol confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in a PDR16-dependent manner

Complex sphingolipids and sterols are coordinately involved in various cellular functions, e.g. the formation of lipid microdomains. Here we found that budding yeast exhibits resistance to an antifungal drug, aureobasidin A (AbA), an inhibitor of Aur1 catalyzing the synthesis of inositolphosphorylce...

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Detalles Bibliográficos
Autores principales: Fukuda, Shizuka, Kono, Yushi, Ishibashi, Yohei, Tabuchi, Mitsuaki, Tani, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333220/
https://www.ncbi.nlm.nih.gov/pubmed/37429938
http://dx.doi.org/10.1038/s41598-023-38237-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333220/
https://www.ncbi.nlm.nih.gov/pubmed/37429938
http://dx.doi.org/10.1038/s41598-023-38237-z

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