ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade

Despite advances in cancer treatment, immune checkpoint blockade (ICB) only achieves complete response in some patients, illustrating the need to identify resistance mechanisms. Using an ICB-insensitive tumor model, here we discover cisplatin enhances the anti-tumor effect of PD-L1 blockade and upre...

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Detalles Bibliográficos
Autores principales: Liu, Xiaolan, Cen, Xufeng, Wu, Ronghai, Chen, Ziyan, Xie, Yanqi, Wang, Fengqi, Shan, Bing, Zeng, Linghui, Zhou, Jichun, Xie, Bojian, Cai, Yangjun, Huang, Jinyan, Liang, Yingjiqiong, Wu, Youqian, Zhang, Chao, Wang, Dongrui, Xia, Hongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333294/
https://www.ncbi.nlm.nih.gov/pubmed/37429863
http://dx.doi.org/10.1038/s41467-023-39920-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333294/
https://www.ncbi.nlm.nih.gov/pubmed/37429863
http://dx.doi.org/10.1038/s41467-023-39920-5

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