Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation

Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes an...

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Detalles Bibliográficos
Autores principales: Orth, Martin F., Surdez, Didier, Faehling, Tobias, Ehlers, Anna C., Marchetto, Aruna, Grossetête, Sandrine, Volckmann, Richard, Zwijnenburg, Danny A., Gerke, Julia S., Zaidi, Sakina, Alonso, Javier, Sastre, Ana, Baulande, Sylvain, Sill, Martin, Cidre-Aranaz, Florencia, Ohmura, Shunya, Kirchner, Thomas, Hauck, Stefanie M., Reischl, Eva, Gymrek, Melissa, Pfister, Stefan M., Strauch, Konstantin, Koster, Jan, Delattre, Olivier, Grünewald, Thomas G.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333306/
https://www.ncbi.nlm.nih.gov/pubmed/36476851
http://dx.doi.org/10.1016/j.celrep.2022.111761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333306/
https://www.ncbi.nlm.nih.gov/pubmed/36476851
http://dx.doi.org/10.1016/j.celrep.2022.111761

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