Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure

This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The inhibition of SLC7A11 transcription was weakened a...

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Autores principales: Li, Wenyuan, Li, Wei, Li, Xun, Wang, Luwen, Wang, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333398/
https://www.ncbi.nlm.nih.gov/pubmed/37243773
http://dx.doi.org/10.1007/s10495-023-01856-y
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author Li, Wenyuan
Li, Wei
Li, Xun
Wang, Luwen
Wang, Yao
author_facet Li, Wenyuan
Li, Wei
Li, Xun
Wang, Luwen
Wang, Yao
author_sort Li, Wenyuan
collection PubMed
description This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The inhibition of SLC7A11 transcription was weakened after blocking of P53 binding to the promoter region of the SLC7A11 gene. The SLC7A11-GSH-GPX4 antiferroptotic pathway was subsequently activated, and the level of ferroptosis in ALF hepatocytes was inhibited.
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spelling pubmed-103333982023-07-12 Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure Li, Wenyuan Li, Wei Li, Xun Wang, Luwen Wang, Yao Apoptosis Article This study investigated whether G3BP1 could regulate ferroptosis in hepatocytes during ALF by affecting the entry of P53 into the nucleus. Promoting G3BP1 expression could inhibit P53 entry by binding to the nuclear localization sequence of P53. The inhibition of SLC7A11 transcription was weakened after blocking of P53 binding to the promoter region of the SLC7A11 gene. The SLC7A11-GSH-GPX4 antiferroptotic pathway was subsequently activated, and the level of ferroptosis in ALF hepatocytes was inhibited. Springer US 2023-05-27 2023 /pmc/articles/PMC10333398/ /pubmed/37243773 http://dx.doi.org/10.1007/s10495-023-01856-y Text en © The Author(s) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Li, Wenyuan
Li, Wei
Li, Xun
Wang, Luwen
Wang, Yao
Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
title Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
title_full Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
title_fullStr Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
title_full_unstemmed Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
title_short Effect of P53 nuclear localization mediated by G3BP1 on ferroptosis in acute liver failure
title_sort effect of p53 nuclear localization mediated by g3bp1 on ferroptosis in acute liver failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333398/
https://www.ncbi.nlm.nih.gov/pubmed/37243773
http://dx.doi.org/10.1007/s10495-023-01856-y
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