Variability of the innate immune response is globally constrained by transcriptional bursting

Transcription of almost all mammalian genes occurs in stochastic bursts, however the fundamental control mechanisms that allow appropriate single-cell responses remain unresolved. Here we utilise single cell genomics data and stochastic models of transcription to perform global analysis of the toll-...

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Detalles Bibliográficos
Autores principales: Alachkar, Nissrin, Norton, Dale, Wolkensdorfer, Zsofia, Muldoon, Mark, Paszek, Pawel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333517/
https://www.ncbi.nlm.nih.gov/pubmed/37441161
http://dx.doi.org/10.3389/fmolb.2023.1176107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333517/
https://www.ncbi.nlm.nih.gov/pubmed/37441161
http://dx.doi.org/10.3389/fmolb.2023.1176107

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