Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma

Mounting evidence suggests that the gut microbiota plays a crucial role in the development and treatment of various cancers. Recent research on the urinary microbiota challenges the long-standing belief that urine is sterile, as urinary microbiota has been implicated in the development of bladder an...

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Autores principales: Yang, Jian-wei, Wan, Shun, Li, Kun-peng, Chen, Si-Yu, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333567/
https://www.ncbi.nlm.nih.gov/pubmed/37441065
http://dx.doi.org/10.3389/fimmu.2023.1188520
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author Yang, Jian-wei
Wan, Shun
Li, Kun-peng
Chen, Si-Yu
Yang, Li
author_facet Yang, Jian-wei
Wan, Shun
Li, Kun-peng
Chen, Si-Yu
Yang, Li
author_sort Yang, Jian-wei
collection PubMed
description Mounting evidence suggests that the gut microbiota plays a crucial role in the development and treatment of various cancers. Recent research on the urinary microbiota challenges the long-standing belief that urine is sterile, as urinary microbiota has been implicated in the development of bladder and prostate cancers, similar to the role of gut microbiota in cancer development. Although the precise involvement of microbiota in the proliferation and differentiation of renal cell carcinoma (RCC) remains unclear, dysbiosis is considered one possible mechanism by which microbiota may contribute to RCC development and treatment. This review summarizes potential mechanisms by which gut microbiota may contribute to the development of RCC, and provides evidence for the involvement of urinary microbiota in RCC. We also explore the role of gut microbiota in RCC treatment and propose that the composition of gut microbiota could serve as a predictive marker for the potential efficacy of immune checkpoint inhibitors (ICIs) in RCC patients. Additionally, evidence suggests that modulating the abundance and distribution of microbiota can enhance the therapeutic effects of drugs, suggesting that microbiota may serve as a promising adjuvant therapy for RCC. Overall, we believe that further investigation into the gut and urinary microbiome of RCC patients could yield valuable insights and strategies for the prevention and personalized treatment of RCC.
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spelling pubmed-103335672023-07-12 Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma Yang, Jian-wei Wan, Shun Li, Kun-peng Chen, Si-Yu Yang, Li Front Immunol Immunology Mounting evidence suggests that the gut microbiota plays a crucial role in the development and treatment of various cancers. Recent research on the urinary microbiota challenges the long-standing belief that urine is sterile, as urinary microbiota has been implicated in the development of bladder and prostate cancers, similar to the role of gut microbiota in cancer development. Although the precise involvement of microbiota in the proliferation and differentiation of renal cell carcinoma (RCC) remains unclear, dysbiosis is considered one possible mechanism by which microbiota may contribute to RCC development and treatment. This review summarizes potential mechanisms by which gut microbiota may contribute to the development of RCC, and provides evidence for the involvement of urinary microbiota in RCC. We also explore the role of gut microbiota in RCC treatment and propose that the composition of gut microbiota could serve as a predictive marker for the potential efficacy of immune checkpoint inhibitors (ICIs) in RCC patients. Additionally, evidence suggests that modulating the abundance and distribution of microbiota can enhance the therapeutic effects of drugs, suggesting that microbiota may serve as a promising adjuvant therapy for RCC. Overall, we believe that further investigation into the gut and urinary microbiome of RCC patients could yield valuable insights and strategies for the prevention and personalized treatment of RCC. Frontiers Media S.A. 2023-06-27 /pmc/articles/PMC10333567/ /pubmed/37441065 http://dx.doi.org/10.3389/fimmu.2023.1188520 Text en Copyright © 2023 Yang, Wan, Li, Chen and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Jian-wei
Wan, Shun
Li, Kun-peng
Chen, Si-Yu
Yang, Li
Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
title Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
title_full Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
title_fullStr Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
title_full_unstemmed Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
title_short Gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
title_sort gut and urinary microbiota: the causes and potential treatment measures of renal cell carcinoma
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333567/
https://www.ncbi.nlm.nih.gov/pubmed/37441065
http://dx.doi.org/10.3389/fimmu.2023.1188520
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