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One-carbon metabolism is required for epigenetic stability in the mouse placenta

One-carbon metabolism, including the folate cycle, has a crucial role in fetal development though its molecular function is complex and unclear. The hypomorphic Mtrr ( gt ) allele is known to disrupt one-carbon metabolism, and thus methyl group availability, leading to several developmental phenotyp...

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Detalles Bibliográficos
Autores principales: Senner, Claire E., Dong, Ziqi, Prater, Malwina, Branco, Miguel R., Watson, Erica D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333575/
https://www.ncbi.nlm.nih.gov/pubmed/37440923
http://dx.doi.org/10.3389/fcell.2023.1209928