Dual targeting of protein translation and nuclear protein export results in enhanced antimyeloma effects

Selinexor (KPT-330) is a small molecule inhibitor of XPO1, which mediates the transport of tumor suppressor proteins, oncogene messenger RNAs, and other proteins involved in governing cell growthfrom the cell nucleus to the cytoplasm. It is overexpressed in many cancer types. Because eukaryotic tran...

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Detalles Bibliográficos
Autores principales: Li, Shirong, Fu, Jing, Walker, Christopher J., Yang, Jun, Bhutani, Divaya, Chakraborty, Rajshekhar, Mamillapalli, Niha, Mapara, Markus Y., Landesman, Yosef, Lentzsch, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Immunobiology and Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333745/
https://www.ncbi.nlm.nih.gov/pubmed/36827679
http://dx.doi.org/10.1182/bloodadvances.2021006638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333745/
https://www.ncbi.nlm.nih.gov/pubmed/36827679
http://dx.doi.org/10.1182/bloodadvances.2021006638

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