PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release

Adherent-invasive Escherichia coli (AIEC) have been implicated in the aetiology of Crohn’s disease (CD). They are characterized by an ability to adhere to and invade intestinal epithelial cells, and to replicate intracellularly in macrophages resulting in inflammation. Proline-rich tyrosine kinase 2...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Ormsby, Michael J., Fallata, Ghaith, Meikle, Lynsey M., Walker, Daniel, Xu, Damo, Wall, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Microbial Virulence and Pathogenesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333790/
https://www.ncbi.nlm.nih.gov/pubmed/37311220
http://dx.doi.org/10.1099/mic.0.001337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10333790/
https://www.ncbi.nlm.nih.gov/pubmed/37311220
http://dx.doi.org/10.1099/mic.0.001337

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