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Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review

Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of non-digestible carbohydrates in the gastrointestinal tract. They can be seen as the major flow of carbon from the diet, through the microbiome to the host. SCFAs have been reported as important molecules r...

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Autores principales: Chalova, Petra, Tazky, Anton, Skultety, Ludovit, Minichova, Lenka, Chovanec, Michal, Ciernikova, Sona, Mikus, Peter, Piestansky, Juraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334191/
https://www.ncbi.nlm.nih.gov/pubmed/37441422
http://dx.doi.org/10.3389/fonc.2023.1110235
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author Chalova, Petra
Tazky, Anton
Skultety, Ludovit
Minichova, Lenka
Chovanec, Michal
Ciernikova, Sona
Mikus, Peter
Piestansky, Juraj
author_facet Chalova, Petra
Tazky, Anton
Skultety, Ludovit
Minichova, Lenka
Chovanec, Michal
Ciernikova, Sona
Mikus, Peter
Piestansky, Juraj
author_sort Chalova, Petra
collection PubMed
description Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of non-digestible carbohydrates in the gastrointestinal tract. They can be seen as the major flow of carbon from the diet, through the microbiome to the host. SCFAs have been reported as important molecules responsible for the regulation of intestinal homeostasis. Moreover, these molecules have a significant impact on the immune system and are able to affect inflammation, cardiovascular diseases, diabetes type II, or oncological diseases. For this purpose, SCFAs could be used as putative biomarkers of various diseases, including cancer. A potential diagnostic value may be offered by analyzing SCFAs with the use of advanced analytical approaches such as gas chromatography (GC), liquid chromatography (LC), or capillary electrophoresis (CE) coupled with mass spectrometry (MS). The presented review summarizes the importance of analyzing SCFAs from clinical and analytical perspective. Current advances in the analysis of SCFAs focused on sample pretreatment, separation strategy, and detection methods are highlighted. Additionally, it also shows potential areas for the development of future diagnostic tools in oncology and other varieties of diseases based on targeted metabolite profiling.
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spelling pubmed-103341912023-07-12 Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review Chalova, Petra Tazky, Anton Skultety, Ludovit Minichova, Lenka Chovanec, Michal Ciernikova, Sona Mikus, Peter Piestansky, Juraj Front Oncol Oncology Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of non-digestible carbohydrates in the gastrointestinal tract. They can be seen as the major flow of carbon from the diet, through the microbiome to the host. SCFAs have been reported as important molecules responsible for the regulation of intestinal homeostasis. Moreover, these molecules have a significant impact on the immune system and are able to affect inflammation, cardiovascular diseases, diabetes type II, or oncological diseases. For this purpose, SCFAs could be used as putative biomarkers of various diseases, including cancer. A potential diagnostic value may be offered by analyzing SCFAs with the use of advanced analytical approaches such as gas chromatography (GC), liquid chromatography (LC), or capillary electrophoresis (CE) coupled with mass spectrometry (MS). The presented review summarizes the importance of analyzing SCFAs from clinical and analytical perspective. Current advances in the analysis of SCFAs focused on sample pretreatment, separation strategy, and detection methods are highlighted. Additionally, it also shows potential areas for the development of future diagnostic tools in oncology and other varieties of diseases based on targeted metabolite profiling. Frontiers Media S.A. 2023-06-27 /pmc/articles/PMC10334191/ /pubmed/37441422 http://dx.doi.org/10.3389/fonc.2023.1110235 Text en Copyright © 2023 Chalova, Tazky, Skultety, Minichova, Chovanec, Ciernikova, Mikus and Piestansky https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chalova, Petra
Tazky, Anton
Skultety, Ludovit
Minichova, Lenka
Chovanec, Michal
Ciernikova, Sona
Mikus, Peter
Piestansky, Juraj
Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
title Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
title_full Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
title_fullStr Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
title_full_unstemmed Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
title_short Determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
title_sort determination of short-chain fatty acids as putative biomarkers of cancer diseases by modern analytical strategies and tools: a review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334191/
https://www.ncbi.nlm.nih.gov/pubmed/37441422
http://dx.doi.org/10.3389/fonc.2023.1110235
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