Inhibition of histone methyltransferase PRMT5 attenuates cisplatin-induced hearing loss through the PI3K/Akt-mediated mitochondrial apoptotic pathway

This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5 (PRMT5) in cisplatin-induced hearing loss. The effects of PRMT5 inhibition on cisplatin-induced auditory injury were determined using immunohistochemistry, apoptosis assays, and auditory brainst...

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Detalles Bibliográficos
Autores principales: Zheng, Zhiwei, Nan, Benyu, Liu, Chang, Tang, Dongmei, Li, Wen, Zhao, Liping, Nie, Guohui, He, Yingzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Xi'an Jiaotong University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334280/
https://www.ncbi.nlm.nih.gov/pubmed/37440906
http://dx.doi.org/10.1016/j.jpha.2023.04.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334280/
https://www.ncbi.nlm.nih.gov/pubmed/37440906
http://dx.doi.org/10.1016/j.jpha.2023.04.014

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