Cargando…

Effects and translatomics characteristics of a small-molecule inhibitor of METTL3 against non-small cell lung cancer

In non-small cell lung cancer (NSCLC), the heterogeneity promotes drug resistance, and the restricted expression of programmed death-ligand 1 (PD-L1) limits the immunotherapy benefits. Based on the mechanisms related to translation regulation and the association with PD-L1 of methyltransferase-like...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Han, Zhao, Rong, Meng, Wangyang, Liao, Yongde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334285/ https://www.ncbi.nlm.nih.gov/pubmed/37440912 http://dx.doi.org/10.1016/j.jpha.2023.04.009

Ejemplares similares

Critical Roles of METTL3 in Translation Regulation of Cancer
por: Meng, Wangyang, et al.
Publicado: (2023)

Stearoyl-CoA Desaturases1 Accelerates Non-Small Cell Lung Cancer Metastasis by Promoting Aromatase Expression to Improve Estrogen Synthesis
por: Chen, Jiaping, et al.
Publicado: (2023)

Upregulation of estrogen receptor beta protein but not mRNA predicts poor prognosis and may be associated with enhanced translation in non-small cell lung cancer: a systematic review and meta-analysis
por: Meng, Wangyang, et al.
Publicado: (2021)

Discovery of METTL3 Small Molecule Inhibitors by Virtual Screening of Natural Products
por: Du, Yue, et al.
Publicado: (2022)

METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey
por: Fiorentino, Francesco, et al.
Publicado: (2023)

P1334: THE IMPACT OF SMALL MOLECULE INHIBITION OF METTL3 ON NORMAL HAEMATOPOIESIS
por: Sturgess, Katherine, et al.
Publicado: (2023)

A five-gene expression signature of centromeric proteins with prognostic value in lung adenocarcinoma
por: Wang, Yangwei, et al.
Publicado: (2023)

The Prognostic Value of Bone Morphogenetic Proteins and Their Receptors in Lung Adenocarcinoma
por: Meng, Wangyang, et al.
Publicado: (2021)

Novel small molecule EGFR inhibitors as candidate drugs in non-small cell lung cancer
por: Berardi, Rossana, et al.
Publicado: (2013)

Development of Small-Molecule Inhibitors Against Zika Virus Infection
por: Wang, Lili, et al.
Publicado: (2019)

METTL7B Is Required for Cancer Cell Proliferation and Tumorigenesis in Non-Small Cell Lung Cancer
por: Liu, Dongcheng, et al.
Publicado: (2020)

Molecular Characteristics of RAGE and Advances in Small-Molecule Inhibitors
por: Kim, Hyeon Jin, et al.
Publicado: (2021)

METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy
por: Sun, Yueqin, et al.
Publicado: (2023)

Translatomics: The Global View of Translation
por: Zhao, Jing, et al.
Publicado: (2019)

Insights Into Translatomics in the Nervous System
por: Zhang, Shuxia, et al.
Publicado: (2020)

TranslatomeDB: a comprehensive database and cloud-based analysis platform for translatome sequencing data
por: Liu, Wanting, et al.
Publicado: (2018)

Salvage surgery following downstaging of advanced non‐small cell lung cancer by targeted therapy
por: Li, Kuo, et al.
Publicado: (2021)

Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression
por: Yang, Fang, et al.
Publicado: (2021)

Small Molecule Inhibitors of Influenza Virus Entry
por: Chen, Zhaoyu, et al.
Publicado: (2021)

Identification of Small Molecule Inhibitors against Mycobacteria in Activated Macrophages
por: Vande Voorde, Rebecca, et al.
Publicado: (2022)

Identification of small molecule inhibitors of Interleukin-18
por: Krumm, Brian, et al.
Publicado: (2017)

Effects of Kasugamycin on the Translatome of Escherichia coli
por: Lange, Christian, et al.
Publicado: (2017)

Data on translatome analysis of Mycoplasma gallisepticum
por: Fisunov, G.Y., et al.
Publicado: (2016)

Transcriptome and translatome co-evolution in mammals
por: Wang, Zhong-Yi, et al.
Publicado: (2020)

Toxicity with small molecule and immunotherapy combinations in non-small cell lung cancer
por: Adderley, H., et al.
Publicado: (2020)

The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules
por: Zhong, Yanwen, et al.
Publicado: (2019)

Small molecule inhibitors of IRES-mediated translation
por: Vaklavas, Christos, et al.
Publicado: (2015)

RNA m6A methyltransferase METTL14 promotes the procession of non‐small cell lung cancer by targeted CSF1R
por: Ren, Siying, et al.
Publicado: (2022)

Proteomics reveal cap-dependent translation inhibitors remodel the translation machinery and translatome
por: Ho, J.J. David, et al.
Publicado: (2021)

Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer
por: Zhang, Yan, et al.
Publicado: (2020)

The pathogenesis of mesothelioma is driven by a dysregulated translatome
por: Grosso, Stefano, et al.
Publicado: (2021)

Recent advances in developing small-molecule inhibitors against SARS-CoV-2
por: Xiang, Rong, et al.
Publicado: (2022)

Molecular modeling and docking of small molecule inhibitors against NEK2
por: Ramachandran, Balaji, et al.
Publicado: (2016)

Identification of Small Molecule Inhibitors of the Pathogen Box against Vibrio cholerae
por: Kim, Haeun, et al.
Publicado: (2021)

MEK inhibitors against MET-amplified non-small cell lung cancer
por: Chiba, Masato, et al.
Publicado: (2016)

Small Molecule Inhibitors of CXCR4
por: Debnath, Bikash, et al.
Publicado: (2013)

Small Molecule Allosteric Inhibitors of BAX
por: Garner, Thomas P., et al.
Publicado: (2019)

Small Molecule Inhibitors of CRM1
por: Ferreira, Bibiana I., et al.
Publicado: (2020)

Small-molecule inhibitors of carboxylesterase Notum
por: Zhao, Yuguang, et al.
Publicado: (2021)

Small molecule inhibitors targeting the cancers
por: Liu, Gui‐Hong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_co079siknqje17rfgh01eo5h8d