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A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis
OBJECTIVE: Mindfulness is an established approach to reduce distress and stress reactivity by improving awareness and tolerability of thoughts and emotions. This study compares mindfulness training to sleep hygiene in persons with multiple sclerosis (PWMS) who report chronic insomnia, examining slee...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334613/ https://www.ncbi.nlm.nih.gov/pubmed/37434109 http://dx.doi.org/10.1186/s12883-023-03309-0 |
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author | Guarnaccia, Joseph B. Njike, Valentine Y. Dutton, Anne Ayettey, Rockiy G. Treu, Judith A. Comerford, Beth P. Sinha, Rajita |
author_facet | Guarnaccia, Joseph B. Njike, Valentine Y. Dutton, Anne Ayettey, Rockiy G. Treu, Judith A. Comerford, Beth P. Sinha, Rajita |
author_sort | Guarnaccia, Joseph B. |
collection | PubMed |
description | OBJECTIVE: Mindfulness is an established approach to reduce distress and stress reactivity by improving awareness and tolerability of thoughts and emotions. This study compares mindfulness training to sleep hygiene in persons with multiple sclerosis (PWMS) who report chronic insomnia, examining sleep efficiency (SE), self-reported sleep quality and quality of life. METHODS: Fifty-three PWMS were randomized (1:1) in a single-blinded, parallel group design to ten, two-hour weekly sessions of Mindfulness Based Stress Intervention for Insomnia (MBSI-I) over a span of ten weeks or a single, one hour sleep hygiene (SH) session over one day. The primary outcome measure was SE, measured by the Fitbit™ Charge 2 wrist device, at 10 and 16 weeks from the start of study interventions. Self-report outcomes included the Pittsburg Sleep Quality Rating Scale (PSQI), Insomnia Severity Index (ISI) and the Multiple Sclerosis Quality of Life Inventory (MSQLI). Nineteen participants in the MBSI-I group and 24 in the SH group completed the primary study. Subsequently, ten participants in the original SH group participated in the 10-week MSBI-I course and their data was added to the MBSI-I cohort (eMSBI-I). RESULTS: While neither SE nor the PSQI showed significant differences between MBSI-I, eMBSI-I and SH groups, ISI improved in both the MSBI-I and eMBSI-I vs SH at 10 weeks (p = 0.0014 and p = 0.0275) but not 16 weeks. However, pre and post assessments within the MBSI-I and eMBSI-I cohorts did show significant improvement in the PSQI and ISI at 10 and 16 weeks, while SH was significant in the ISI only at 16 weeks. Several quality of life measurements, including fatigue, mental health and cognitive function favored the mindfulness cohorts. CONCLUSION: This pilot study demonstrates beneficial effects of MBSR on insomnia, sleep quality and quality of life in PWMS. TRIAL REGISTRATION: NCT03949296. 14 May 2019. |
format | Online Article Text |
id | pubmed-10334613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103346132023-07-12 A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis Guarnaccia, Joseph B. Njike, Valentine Y. Dutton, Anne Ayettey, Rockiy G. Treu, Judith A. Comerford, Beth P. Sinha, Rajita BMC Neurol Research OBJECTIVE: Mindfulness is an established approach to reduce distress and stress reactivity by improving awareness and tolerability of thoughts and emotions. This study compares mindfulness training to sleep hygiene in persons with multiple sclerosis (PWMS) who report chronic insomnia, examining sleep efficiency (SE), self-reported sleep quality and quality of life. METHODS: Fifty-three PWMS were randomized (1:1) in a single-blinded, parallel group design to ten, two-hour weekly sessions of Mindfulness Based Stress Intervention for Insomnia (MBSI-I) over a span of ten weeks or a single, one hour sleep hygiene (SH) session over one day. The primary outcome measure was SE, measured by the Fitbit™ Charge 2 wrist device, at 10 and 16 weeks from the start of study interventions. Self-report outcomes included the Pittsburg Sleep Quality Rating Scale (PSQI), Insomnia Severity Index (ISI) and the Multiple Sclerosis Quality of Life Inventory (MSQLI). Nineteen participants in the MBSI-I group and 24 in the SH group completed the primary study. Subsequently, ten participants in the original SH group participated in the 10-week MSBI-I course and their data was added to the MBSI-I cohort (eMSBI-I). RESULTS: While neither SE nor the PSQI showed significant differences between MBSI-I, eMBSI-I and SH groups, ISI improved in both the MSBI-I and eMBSI-I vs SH at 10 weeks (p = 0.0014 and p = 0.0275) but not 16 weeks. However, pre and post assessments within the MBSI-I and eMBSI-I cohorts did show significant improvement in the PSQI and ISI at 10 and 16 weeks, while SH was significant in the ISI only at 16 weeks. Several quality of life measurements, including fatigue, mental health and cognitive function favored the mindfulness cohorts. CONCLUSION: This pilot study demonstrates beneficial effects of MBSR on insomnia, sleep quality and quality of life in PWMS. TRIAL REGISTRATION: NCT03949296. 14 May 2019. BioMed Central 2023-07-11 /pmc/articles/PMC10334613/ /pubmed/37434109 http://dx.doi.org/10.1186/s12883-023-03309-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Guarnaccia, Joseph B. Njike, Valentine Y. Dutton, Anne Ayettey, Rockiy G. Treu, Judith A. Comerford, Beth P. Sinha, Rajita A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
title | A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
title_full | A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
title_fullStr | A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
title_full_unstemmed | A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
title_short | A pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
title_sort | pilot, randomized, placebo-controlled study of mindfulness meditation in treating insomnia in multiple sclerosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334613/ https://www.ncbi.nlm.nih.gov/pubmed/37434109 http://dx.doi.org/10.1186/s12883-023-03309-0 |
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