Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3

BACKGROUND: Mammalian metallothioneins (MTs) are small (6–7 kDa), intracellular, cysteine-rich, metal-binding proteins involved, inter alia, in the homeostasis of zinc and copper, detoxification of heavy metals, antioxidation against reactive oxygen species, and protection against DNA damage. The hi...

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Detalles Bibliográficos
Autores principales: Singh, Avinash Kumar, Krężel, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334657/
https://www.ncbi.nlm.nih.gov/pubmed/37434134
http://dx.doi.org/10.1186/s12934-023-02134-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334657/
https://www.ncbi.nlm.nih.gov/pubmed/37434134
http://dx.doi.org/10.1186/s12934-023-02134-x

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