Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors

The G12D mutation is among the most common KRAS mutations associated with cancer, in particular, pancreatic cancer. Here, we have developed monobodies, small synthetic binding proteins, that are selective to KRAS(G12D) over KRAS(wild type) and other oncogenic KRAS mutations, as well as over the G12D...

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Detalles Bibliográficos
Autores principales: Akkapeddi, Padma, Hattori, Takamitsu, Khan, Imran, Glasser, Eliezra, Koide, Akiko, Ketavarapu, Gayatri, Whaby, Michael, Zuberi, Mariyam, Teng, Kai Wen, Lefler, Julia, Maso, Lorenzo, Bang, Injin, Ostrowski, Michael C., O’Bryan, John P., Koide, Shohei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334749/
https://www.ncbi.nlm.nih.gov/pubmed/37399416
http://dx.doi.org/10.1073/pnas.2302485120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334749/
https://www.ncbi.nlm.nih.gov/pubmed/37399416
http://dx.doi.org/10.1073/pnas.2302485120

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