Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound

Although HIV-1 Gag is known to drive viral assembly and budding, the precise mechanisms by which the lipid composition of the plasma membrane is remodeled during assembly are incompletely understood. Here, we provide evidence that the sphingomyelin hydrolase neutral sphingomyelinase 2 (nSMase2) inte...

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Detalles Bibliográficos
Autores principales: Yoo, Seung-Wan, Waheed, Abdul A., Deme, Pragney, Tohumeken, Sehmus, Rais, Rana, Smith, Matthew D., DeMarino, Catherine, Calabresi, Peter A., Kashanchi, Fatah, Freed, Eric O., Slusher, Barbara S., Haughey, Norman J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334757/
https://www.ncbi.nlm.nih.gov/pubmed/37406092
http://dx.doi.org/10.1073/pnas.2219543120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334757/
https://www.ncbi.nlm.nih.gov/pubmed/37406092
http://dx.doi.org/10.1073/pnas.2219543120

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