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Tsp-1(+) microglia attenuate retinal neovascularization by maintaining the expression of Smad3 in endothelial cells through exosomes with decreased miR-27a-5p

Rationale: Microglia with a repertoire of functions are critical in pathological regulation of angiogenesis in the retina. However, retinal microglia with beneficial contributions and corresponding mechanisms during pathological neovascularization are poorly understood. Methods: We conducted a bioin...

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Detalles Bibliográficos
Autores principales: Luo, Qian, Jiang, Zihua, Jiang, Jingyi, Wan, Linxi, Li, Yan, Huang, Yuke, Qiu, Jin, Yu, Keming, Zhuang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334831/
https://www.ncbi.nlm.nih.gov/pubmed/37441592
http://dx.doi.org/10.7150/thno.84236