Cargando…

Single-cell RNA sequencing identifies critical transcription factors of tumor cell invasion induced by hypoxia microenvironment in glioblastoma

Rationale: Glioblastoma (GBM) is an aggressive malignant primary brain cancer with poor survival. Hypoxia is a hallmark of GBM, which promotes tumor cells spreading (invasion) into the healthy brain tissue. Methods: To better elucidate the influence of hypoxia on GBM invasion, we proposed a data-dri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yanru, Zhang, Bo, Lv, Chengqian, Zhang, Nan, Xing, Kaiyuan, Wang, Zixuan, Lv, Rongkai, Yu, Mingchen, Xu, Chaohan, Wang, Yihan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334835/ https://www.ncbi.nlm.nih.gov/pubmed/37441593 http://dx.doi.org/10.7150/thno.81407

Ejemplares similares

Systemically Identifying Triple-Negative Breast Cancer Subtype-Specific Prognosis Signatures, Based on Single-Cell RNA-Seq Data
por: Xing, Kaiyuan, et al.
Publicado: (2023)

Identification of Prognostic Gene Signatures by Developing a scRNA-Seq-Based Integration Approach to Predict Recurrence and Chemotherapy Benefit in Stage II–III Colorectal Cancer
por: Wang, Zixuan, et al.
Publicado: (2022)

The genotypic and phenotypic impact of hypoxia microenvironment on glioblastoma cell lines
por: Macharia, Lucy Wanjiku, et al.
Publicado: (2021)

Identification of Immune Cell Infiltration and Immune-Related Genes in the Tumor Microenvironment of Glioblastomas
por: Huang, Sicong, et al.
Publicado: (2020)

Effects of Hypoxia in Intestinal Tumors on Immune Cell Behavior in the Tumor Microenvironment
por: Zhang, Luping, et al.
Publicado: (2021)

Behaviors of Glioblastoma Cells in in Vitro Microenvironments
por: Diao, Wenwen, et al.
Publicado: (2019)

Fucosyltransferase 4 Predicts Patient Outcome in Rectal Cancer through an Immune Microenvironment-Mediated Multi-Mechanism
por: Lv, Chengqian, et al.
Publicado: (2022)

CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway
por: Mao, Xing-gang, et al.
Publicado: (2023)

The critical role of ERK in death resistance and invasiveness of hypoxia-selected glioblastoma cells
por: Kim, Jee-Youn, et al.
Publicado: (2009)

Myeloid Cells in Glioblastoma Microenvironment
por: De Leo, Alessandra, et al.
Publicado: (2020)

Increased mitochondrial fission is critical for hypoxia-induced pancreatic beta cell death
por: Zhang, Da, et al.
Publicado: (2018)

The Role of Hypoxia and Cancer Stem Cells in Development of Glioblastoma
por: Shi, Tingyu, et al.
Publicado: (2023)

Hypoxia increases the expression of stem cell markers in human osteosarcoma cells
por: Lin, Jinluan, et al.
Publicado: (2021)

RNA modification patterns based on major RNA modifications define tumor microenvironment characteristics in glioblastoma
por: Li, Ganglei, et al.
Publicado: (2022)

The immunosuppressive microenvironment and immunotherapy in human glioblastoma
por: Zhang, Xuehua, et al.
Publicado: (2022)

Identification of a unique tumor cell subset employing myeloid transcriptional circuits to create an immunomodulatory microenvironment in glioblastoma
por: Yang, Kaidi, et al.
Publicado: (2022)

Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide
por: Lorenz, Nadja I., et al.
Publicado: (2021)

Integrated Analysis of Angiogenesis-Mediated Tumor Immune Microenvironment Pattern in Hepatocellular Carcinoma (HCC) and a Novel Prognostic Model Construction to Predict Patient Outcome
por: Lv, Chengqian, et al.
Publicado: (2021)

Identifying Hypoxia Characteristics to Stratify Prognosis and Assess the Tumor Immune Microenvironment in Renal Cell Carcinoma
por: Zhang, Zhenan, et al.
Publicado: (2021)

Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma
por: Wang, Zeyu, et al.
Publicado: (2023)

Proteomics-based prognostic signature and nomogram construction of hypoxia microenvironment on deteriorating glioblastoma (GBM) pathogenesis
por: Wen, Ya-Dan, et al.
Publicado: (2021)

Glioblastoma multiforme: Effect of hypoxia and hypoxia inducible factors on therapeutic approaches
por: Huang, Wen-Juan, et al.
Publicado: (2016)

Hypoxia and glioblastoma therapy
por: Yang, Chunzhang, et al.
Publicado: (2015)

Hypoxia: The Cornerstone of Glioblastoma
por: Domènech, Marta, et al.
Publicado: (2021)

Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate
por: Yin, Chengqian, et al.
Publicado: (2016)

Pentraxin 3 Promotes Glioblastoma Progression by Negative Regulating Cells Autophagy
por: Wang, Zeyu, et al.
Publicado: (2020)

Glioblastoma Stem-Like Cells: Characteristics, Microenvironment, and Therapy
por: Yi, Yang, et al.
Publicado: (2016)

Hypoxia and the Tumor Microenvironment
por: Li, Yue, et al.
Publicado: (2021)

Comprehensive analysis of pyroptosis‐related gene signatures for glioblastoma immune microenvironment and target therapy
por: Wang, Zeyu, et al.
Publicado: (2023)

Network Pharmacology and Inflammatory Microenvironment Strategy Approach to Finding the Potential Target of Siraitia grosvenorii (Luo Han Guo) for Glioblastoma
por: Li, Juan, et al.
Publicado: (2021)

Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma
por: Mao, Xing-gang, et al.
Publicado: (2016)

Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia
por: Richards, Rosalie, et al.
Publicado: (2016)

Ultrasound-triggered biomimetic ultrashort peptide nanofiber hydrogels promote bone regeneration by modulating macrophage and the osteogenic immune microenvironment
por: Zhang, Fan, et al.
Publicado: (2023)

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment
por: Feng, Jianbo, et al.
Publicado: (2018)

Single-Cell Atlas Reveals Complexity of the Immunosuppressive Microenvironment of Initial and Recurrent Glioblastoma
por: Fu, Weilun, et al.
Publicado: (2020)

Heterogeneity and individualized treatment of microenvironment in glioblastoma (Review)
por: Kang, Wei, et al.
Publicado: (2023)

Protective effect of c-Myc/Rab7a signal pathway in glioblastoma cells under hypoxia
por: Li, Chenguang, et al.
Publicado: (2020)

Role of hypoxia-inducible factor-1α in autophagic cell death in microglial cells induced by hypoxia
por: Wang, Xintao, et al.
Publicado: (2017)

Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
por: Jeanmougin, Marine, et al.
Publicado: (2020)

Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma
por: Zhang, Wenshuo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_nrn9pdaqbdpo6ob2g9jodfoac1