Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis

Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis. Patients with inflammatory bowel diseases, such as ulcerative colitis, display changes in their microbiota with the expans...

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Detalles Bibliográficos
Autores principales: Harnack, Christine, Berger, Hilmar, Liu, Lichao, Mollenkopf, Hans-Joachim, Strowig, Till, Sigal, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334853/
https://www.ncbi.nlm.nih.gov/pubmed/37427832
http://dx.doi.org/10.1080/19490976.2023.2233689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10334853/
https://www.ncbi.nlm.nih.gov/pubmed/37427832
http://dx.doi.org/10.1080/19490976.2023.2233689

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