The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition

The tumor suppressor TP53 is the most frequently mutated gene in cancer and is mutationally inactivated in 50% of sporadic tumors. Inactivating mutations in TP53 also occur in Li Fraumeni syndrome (LFS). In addition to germline mutations in TP53 in LFS that completely inactivate this protein, there...

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Detalles Bibliográficos
Autores principales: Stieg, David C., Parris, Joshua L. D., Yang, Tyler Hong Loong, Mirji, Gauri, Reiser, Sarah Kim, Murali, Nivitha, Werts, Madison, Barnoud, Thibaut, Lu, David Y., Shinde, Rahul, Murphy, Maureen E., Claiborne, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335007/
https://www.ncbi.nlm.nih.gov/pubmed/37441266
http://dx.doi.org/10.1158/2767-9764.CRC-23-0149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335007/
https://www.ncbi.nlm.nih.gov/pubmed/37441266
http://dx.doi.org/10.1158/2767-9764.CRC-23-0149

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