Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells

INTRODUCTION: The enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognized hallmarks of aging, its relation to other hallmarks includ...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwasaki, Kanako, Lalani, Benjamin, Kahng, Jiho, Carapeto, Priscila, Sanjines, Stephanie, Hela, Francesko, Abarca, Cristian, Tsuji, Tadataka, Darcy, Justin, Bartke, Andrzej, Tseng, Yu-Hua, Kulkarni, Rohit N., Aguayo-Mazzucato, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335398/
https://www.ncbi.nlm.nih.gov/pubmed/37441495
http://dx.doi.org/10.3389/fendo.2023.1203534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335398/
https://www.ncbi.nlm.nih.gov/pubmed/37441495
http://dx.doi.org/10.3389/fendo.2023.1203534

Ejemplares similares