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Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells

INTRODUCTION: The enhanced β-cell senescence that accompanies insulin resistance and aging contributes to cellular dysfunction and loss of transcriptional identity leading to type 2 diabetes (T2D). While senescence is among the 12 recognized hallmarks of aging, its relation to other hallmarks includ...

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Detalles Bibliográficos
Autores principales:	Iwasaki, Kanako, Lalani, Benjamin, Kahng, Jiho, Carapeto, Priscila, Sanjines, Stephanie, Hela, Francesko, Abarca, Cristian, Tsuji, Tadataka, Darcy, Justin, Bartke, Andrzej, Tseng, Yu-Hua, Kulkarni, Rohit N., Aguayo-Mazzucato, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335398/ https://www.ncbi.nlm.nih.gov/pubmed/37441495 http://dx.doi.org/10.3389/fendo.2023.1203534

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