AI-based multi-PRS models outperform classical single-PRS models

Polygenic risk scores (PRS) calculate the risk for a specific disease based on the weighted sum of associated alleles from different genetic loci in the germline estimated by regression models. Recent advances in genetics made it possible to create polygenic predictors of complex human traits, inclu...

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Detalles Bibliográficos
Autores principales: Klau, Jan Henric, Maj, Carlo, Klinkhammer, Hannah, Krawitz, Peter M., Mayr, Andreas, Hillmer, Axel M., Schumacher, Johannes, Heider, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335560/
https://www.ncbi.nlm.nih.gov/pubmed/37441549
http://dx.doi.org/10.3389/fgene.2023.1217860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335560/
https://www.ncbi.nlm.nih.gov/pubmed/37441549
http://dx.doi.org/10.3389/fgene.2023.1217860

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