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MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres

The active state of centromeres is epigenetically defined by the presence of CENP-A interspersed with histone H3 nucleosomes. While the importance of dimethylation of H3K4 for centromeric transcription has been highlighted in various studies, the identity of the enzyme(s) depositing these marks on t...

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Detalles Bibliográficos
Autores principales: Malik, Kausika Kumar, Sridhara, Sreerama Chaitanya, Lone, Kaisar Ahmad, Katariya, Payal Deepakbhai, Pulimamidi, Deepshika, Tyagi, Shweta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335677/
https://www.ncbi.nlm.nih.gov/pubmed/37379335
http://dx.doi.org/10.1371/journal.pbio.3002161