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Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos
During development, Hox genes are temporally activated according to their relative positions on their clusters, contributing to the proper identities of structures along the rostrocaudal axis. To understand the mechanism underlying this Hox timer, we used mouse embryonic stem cell-derived stembryos....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10335938/ https://www.ncbi.nlm.nih.gov/pubmed/37322110 http://dx.doi.org/10.1038/s41588-023-01426-7 |